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Metabolomics · DNA Turnover Nucleoside — Salivary Analysis

2'-deoxyguanosine

2'-Deoxyguanosine (dG) is the unmodified deoxyribonucleoside released during DNA turnover and repair, serving as the baseline reference against which its oxidised counterpart 8-hydroxy-2'-deoxyguanosine (8-OHdG) is quantified. Measured alongside 8-OHdG in saliva, 2'-deoxyguanosine enables normalisation of the oxidative DNA-damage ratios that rise with high-intensity and eccentric exercise. Valavanidis et al. (2009) established this nucleoside pairing as the basis of the gold-standard oxidative DNA-damage assay.

References

  1. 8-Hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesisValavanidis A et al. · J Environ Sci Health C · 2009 — PubMed
  2. Oxidative stress: relationship with exercise and trainingFinaud J et al. · Sports Med · 2006 — PubMed