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Lipidomics · Stress Glucocorticoid — Salivary Analysis

Cortisol

Cortisol is the primary glucocorticoid hormone of the HPA axis, with salivary concentrations reflecting unbound bioactive free cortisol in plasma without the protein-binding interference present in serum measurements. It is the most extensively validated salivary hormone biomarker, used to quantify physiological stress, circadian rhythm integrity, and HPA axis reactivity across pain, fatigue, inflammation, and overtraining contexts. Chronically elevated salivary cortisol indicates maladaptive stress responses and increased catabolic drive.

References

  1. Hormonal aspects of overtraining syndrome: a systematic reviewCadegiani FA, Kater CE · BMC Sports Sci Med Rehabil · 2017 — PubMed
  2. Salivary cortisol as a biomarker in stress researchHellhammer DH et al. · Psychoneuroendocrinology · 2009 — PubMed
  3. Hormonal responses and adaptations to resistance exercise and trainingKraemer WJ, Ratamess NA · Sports Med · 2005 — PubMed
  4. Low energy availability, not stress of exercise, alters LH pulsatility in exercising womenLoucks AB et al. · J Appl Physiol · 1998 — PubMed
  5. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress?Smith LL · Med Sci Sports Exerc · 2000 — PubMed
  6. The physiologic effects of pain on the endocrine systemTennant F · Pain Ther · 2013 — PubMed