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Lipidomics · Cortisol Metabolite — Salivary Analysis

Cortisone

Cortisone is the inactive glucocorticoid metabolite of cortisol, produced by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity in salivary gland cells, and measurable in saliva at concentrations reflecting local glucocorticoid metabolism. Salivary cortisone tracks free cortisol availability and provides an independent measure of HPA axis output complementary to cortisol itself. The cortisol-to-cortisone ratio in saliva is a validated index of 11β-HSD enzyme activity and systemic glucocorticoid exposure.

References

  1. Higher perceived stress but lower cortisol levels found among young Greek adults living in a stressful social environmentFaresjo A et al. · PLoS ONE · 2013 — PubMed
  2. Salivary cortisone is a potential biomarker for serum free cortisolPerogamvros I et al. · J Clin Endocrinol Metab · 2010 — PubMed
  3. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid responseTomlinson JW et al. · Endocr Rev · 2004 — PubMed