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Salivary Creatinine · Kidney Function Marker

Creatinine

Creatinine is a metabolic waste product generated from the breakdown of creatine phosphate in muscle tissue. It is filtered from the blood by the kidneys at a relatively constant rate, making it a reliable endogenous marker of glomerular filtration rate (GFR) and overall kidney function.

In salivary analysis, creatinine concentration provides a non-invasive window into both kidney clearance capacity and hydration status.

References

  1. Mechanisms of aerobic performance impairment with heat stress and dehydrationCheuvront SN et al. · J Appl Physiol · 2010 — PubMed
  2. Saliva flow rate, total protein concentration and osmolality as potential markers of whole body hydration status during progressive acute dehydration in humansWalsh NP et al. · Arch Oral Biol · 2004 — PubMed
  3. Creatine and creatinine metabolismWyss M, Kaddurah-Daouk R. · Physiol Rev · 2000 — PubMed
  4. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equationLevey AS et al. · Ann Intern Med · 1999 — PubMed