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Metabolomics · IDO Pathway Metabolite — Salivary Analysis

Kynurenine

Kynurenine is the first major metabolite of tryptophan catabolism via the kynurenine pathway, produced from tryptophan by indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) in response to pro-inflammatory cytokines and glucocorticoids. Elevated kynurenine indicates activated tryptophan catabolism and is associated with immune activation, inflammation, psychological stress, and overtraining syndrome in athletes. Together with tryptophan and kynurenic acid, salivary kynurenine enables calculation of the Kyn/Trp ratio, a quantitative index of IDO enzyme activity central to Biolyz’s immune monitoring framework.

References

  1. Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental healthCervenka I et al. · Science · 2017 — PubMed
  2. Monitoring tryptophan metabolism in chronic immune activationSchrocksnadel K et al. · Clin Chim Acta · 2006 — PubMed
  3. Kynurenine pathway in major depression: evidence of impaired neuroprotectionMyint AM et al. · J Affect Disord · 2007 — PubMed