Palmitoleoyl ethanolamide

Palmitoleoyl ethanolamide is a monounsaturated N-acylethanolamine, a minor member of the endocannabinoid-like lipid family derived from palmitoleic acid, modulating PPAR-α signalling, inflammation, and metabolic homeostasis. As a salivary lipid it forms part of the N-acylethanolamine signature responsive to physical effort and recovery state. Wenzel et al. (2026) identified palmitoleoyl ethanolamide among the salivary lipids that reliably distinguish recent exercise and contribute to a saliva-based internal-strain score.